This learning module describes the complex neurological condition multiple sclerosis (MS) and its management. It outlines the pathophysiology and symptoms, the importance of timely access to specialist services for treatment of symptoms, and relapse and disease management. New and emerging therapies for the management of MS, the role of the multidisciplinary team, the importance of holistic assessment and the role of the MS specialist nurse are discussed. Self-management of MS is integral to managing this life-limiting long-term condition. While there is no cure for MS, new and oral disease-modifying therapies providing better efficacy in stabilising the disease have recently been introduced, reducing relapse frequency and disease activity, and delaying the progression of disability.